Search | Virtual Health Library

1.

Massively parallel base editing to map variant effects in human hematopoiesis.

Martin-Rufino, Jorge D; Castano, Nicole; Pang, Michael; Grody, Emanuelle I; Joubran, Samantha; Caulier, Alexis; Wahlster, Lara; Li, Tongqing; Qiu, Xiaojie; Riera-Escandell, Anna Maria; Newby, Gregory A; Al'Khafaji, Aziz; Chaudhary, Santosh; Black, Susan; Weng, Chen; Munson, Glen; Liu, David R; Wlodarski, Marcin W; Sims, Kacie; Oakley, Jamie H; Fasano, Ross M; Xavier, Ramnik J; Lander, Eric S; Klein, Daryl E; Sankaran, Vijay G.

Cell ; 186(11): 2456-2474.e24, 2023 05 25.

Article in English | MEDLINE | ID: mdl-37137305

2.

Mapping transcriptomic vector fields of single cells.

Qiu, Xiaojie; Zhang, Yan; Martin-Rufino, Jorge D; Weng, Chen; Hosseinzadeh, Shayan; Yang, Dian; Pogson, Angela N; Hein, Marco Y; Hoi Joseph Min, Kyung; Wang, Li; Grody, Emanuelle I; Shurtleff, Matthew J; Yuan, Ruoshi; Xu, Song; Ma, Yian; Replogle, Joseph M; Lander, Eric S; Darmanis, Spyros; Bahar, Ivet; Sankaran, Vijay G; Xing, Jianhua; Weissman, Jonathan S.

Cell ; 185(4): 690-711.e45, 2022 02 17.

Article in English | MEDLINE | ID: mdl-35108499

3.

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Khera, Amit V; Chaffin, Mark; Wade, Kaitlin H; Zahid, Sohail; Brancale, Joseph; Xia, Rui; Distefano, Marina; Senol-Cosar, Ozlem; Haas, Mary E; Bick, Alexander; Aragam, Krishna G; Lander, Eric S; Smith, George Davey; Mason-Suares, Heather; Fornage, Myriam; Lebo, Matthew; Timpson, Nicholas J; Kaplan, Lee M; Kathiresan, Sekar.

Cell ; 177(3): 587-596.e9, 2019 04 18.

Article in English | MEDLINE | ID: mdl-31002795

4.

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Schiebinger, Geoffrey; Shu, Jian; Tabaka, Marcin; Cleary, Brian; Subramanian, Vidya; Solomon, Aryeh; Gould, Joshua; Liu, Siyan; Lin, Stacie; Berube, Peter; Lee, Lia; Chen, Jenny; Brumbaugh, Justin; Rigollet, Philippe; Hochedlinger, Konrad; Jaenisch, Rudolf; Regev, Aviv; Lander, Eric S.

Cell ; 176(4): 928-943.e22, 2019 02 07.

Article in English | MEDLINE | ID: mdl-30712874

5.

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.

Dvela-Levitt, Moran; Kost-Alimova, Maria; Emani, Maheswarareddy; Kohnert, Eva; Thompson, Rebecca; Sidhom, Eriene-Heidi; Rivadeneira, Ana; Sahakian, Nareh; Roignot, Julie; Papagregoriou, Gregory; Montesinos, Monica S; Clark, Abbe R; McKinney, David; Gutierrez, Juan; Roth, Mark; Ronco, Lucienne; Elonga, Esther; Carter, Todd A; Gnirke, Andreas; Melanson, Michelle; Hartland, Kate; Wieder, Nicolas; Hsu, Jane C-H; Deltas, Constantinos; Hughey, Rebecca; Bleyer, Anthony J; Kmoch, Stanislav; Zivná, Martina; Baresova, Veronika; Kota, Savithri; Schlondorff, Johannes; Heiman, Myriam; Alper, Seth L; Wagner, Florence; Weins, Astrid; Golub, Todd R; Lander, Eric S; Greka, Anna.

Cell ; 178(3): 521-535.e23, 2019 07 25.

Article in English | MEDLINE | ID: mdl-31348885

6.

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Khajuria, Rajiv K; Munschauer, Mathias; Ulirsch, Jacob C; Fiorini, Claudia; Ludwig, Leif S; McFarland, Sean K; Abdulhay, Nour J; Specht, Harrison; Keshishian, Hasmik; Mani, D R; Jovanovic, Marko; Ellis, Steven R; Fulco, Charles P; Engreitz, Jesse M; Schütz, Sabina; Lian, John; Gripp, Karen W; Weinberg, Olga K; Pinkus, Geraldine S; Gehrke, Lee; Regev, Aviv; Lander, Eric S; Gazda, Hanna T; Lee, Winston Y; Panse, Vikram G; Carr, Steven A; Sankaran, Vijay G.

Cell ; 173(1): 90-103.e19, 2018 03 22.

Article in English | MEDLINE | ID: mdl-29551269

7.

Efficient Generation of Transcriptomic Profiles by Random Composite Measurements.

Cleary, Brian; Cong, Le; Cheung, Anthea; Lander, Eric S; Regev, Aviv.

Cell ; 171(6): 1424-1436.e18, 2017 Nov 30.

Article in English | MEDLINE | ID: mdl-29153835

8.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Wang, Tim; Yu, Haiyan; Hughes, Nicholas W; Liu, Bingxu; Kendirli, Arek; Klein, Klara; Chen, Walter W; Lander, Eric S; Sabatini, David M.

Cell ; 168(5): 890-903.e15, 2017 02 23.

Article in English | MEDLINE | ID: mdl-28162770

9.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Kim, Ah Ram; Ulirsch, Jacob C; Wilmes, Stephan; Unal, Ekrem; Moraga, Ignacio; Karakukcu, Musa; Yuan, Daniel; Kazerounian, Shideh; Abdulhay, Nour J; King, David S; Gupta, Namrata; Gabriel, Stacey B; Lander, Eric S; Patiroglu, Turkan; Ozcan, Alper; Ozdemir, Mehmet Akif; Garcia, K Christopher; Piehler, Jacob; Gazda, Hanna T; Klein, Daryl E; Sankaran, Vijay G.

Cell ; 168(6): 1053-1064.e15, 2017 03 09.

Article in English | MEDLINE | ID: mdl-28283061

10.

Cohesin Loss Eliminates All Loop Domains.

Rao, Suhas S P; Huang, Su-Chen; Glenn St Hilaire, Brian; Engreitz, Jesse M; Perez, Elizabeth M; Kieffer-Kwon, Kyong-Rim; Sanborn, Adrian L; Johnstone, Sarah E; Bascom, Gavin D; Bochkov, Ivan D; Huang, Xingfan; Shamim, Muhammad S; Shin, Jaeweon; Turner, Douglass; Ye, Ziyi; Omer, Arina D; Robinson, James T; Schlick, Tamar; Bernstein, Bradley E; Casellas, Rafael; Lander, Eric S; Aiden, Erez Lieberman.

Cell ; 171(2): 305-320.e24, 2017 Oct 05.

Article in English | MEDLINE | ID: mdl-28985562

11.

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.

Rusu, Victor; Hoch, Eitan; Mercader, Josep M; Tenen, Danielle E; Gymrek, Melissa; Hartigan, Christina R; DeRan, Michael; von Grotthuss, Marcin; Fontanillas, Pierre; Spooner, Alexandra; Guzman, Gaelen; Deik, Amy A; Pierce, Kerry A; Dennis, Courtney; Clish, Clary B; Carr, Steven A; Wagner, Bridget K; Schenone, Monica; Ng, Maggie C Y; Chen, Brian H; Centeno-Cruz, Federico; Zerrweck, Carlos; Orozco, Lorena; Altshuler, David M; Schreiber, Stuart L; Florez, Jose C; Jacobs, Suzanne B R; Lander, Eric S.

Cell ; 170(1): 199-212.e20, 2017 Jun 29.

Article in English | MEDLINE | ID: mdl-28666119

12.

The Heroes of CRISPR.

Lander, Eric S.

Cell ; 164(1-2): 18-28, 2016 Jan 14.

Article in English | MEDLINE | ID: mdl-26771483

13.

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.

Tewhey, Ryan; Kotliar, Dylan; Park, Daniel S; Liu, Brandon; Winnicki, Sarah; Reilly, Steven K; Andersen, Kristian G; Mikkelsen, Tarjei S; Lander, Eric S; Schaffner, Stephen F; Sabeti, Pardis C.

Cell ; 165(6): 1519-1529, 2016 Jun 02.

Article in English | MEDLINE | ID: mdl-27259153

14.

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

Dixit, Atray; Parnas, Oren; Li, Biyu; Chen, Jenny; Fulco, Charles P; Jerby-Arnon, Livnat; Marjanovic, Nemanja D; Dionne, Danielle; Burks, Tyler; Raychowdhury, Raktima; Adamson, Britt; Norman, Thomas M; Lander, Eric S; Weissman, Jonathan S; Friedman, Nir; Regev, Aviv.

Cell ; 167(7): 1853-1866.e17, 2016 Dec 15.

Article in English | MEDLINE | ID: mdl-27984732

15.

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.

Cacchiarelli, Davide; Trapnell, Cole; Ziller, Michael J; Soumillon, Magali; Cesana, Marcella; Karnik, Rahul; Donaghey, Julie; Smith, Zachary D; Ratanasirintrawoot, Sutheera; Zhang, Xiaolan; Ho Sui, Shannan J; Wu, Zhaoting; Akopian, Veronika; Gifford, Casey A; Doench, John; Rinn, John L; Daley, George Q; Meissner, Alexander; Lander, Eric S; Mikkelsen, Tarjei S.

Cell ; 162(2): 412-424, 2015 Jul 16.

Article in English | MEDLINE | ID: mdl-26186193

16.

Convergence of coronary artery disease genes onto endothelial cell programs.

Schnitzler, Gavin R; Kang, Helen; Fang, Shi; Angom, Ramcharan S; Lee-Kim, Vivian S; Ma, X Rosa; Zhou, Ronghao; Zeng, Tony; Guo, Katherine; Taylor, Martin S; Vellarikkal, Shamsudheen K; Barry, Aurelie E; Sias-Garcia, Oscar; Bloemendal, Alex; Munson, Glen; Guckelberger, Philine; Nguyen, Tung H; Bergman, Drew T; Hinshaw, Stephen; Cheng, Nathan; Cleary, Brian; Aragam, Krishna; Lander, Eric S; Finucane, Hilary K; Mukhopadhyay, Debabrata; Gupta, Rajat M; Engreitz, Jesse M.

Nature ; 626(8000): 799-807, 2024 Feb.

Article in English | MEDLINE | ID: mdl-38326615

17.

Development and applications of CRISPR-Cas9 for genome engineering.

Hsu, Patrick D; Lander, Eric S; Zhang, Feng.

Cell ; 157(6): 1262-1278, 2014 Jun 05.

Article in English | MEDLINE | ID: mdl-24906146

18.

RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.

Engreitz, Jesse M; Sirokman, Klara; McDonel, Patrick; Shishkin, Alexander A; Surka, Christine; Russell, Pamela; Grossman, Sharon R; Chow, Amy Y; Guttman, Mitchell; Lander, Eric S.

Cell ; 159(1): 188-199, 2014 Sep 25.

Article in English | MEDLINE | ID: mdl-25259926

19.

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Schiebinger, Geoffrey; Shu, Jian; Tabaka, Marcin; Cleary, Brian; Subramanian, Vidya; Solomon, Aryeh; Gould, Joshua; Liu, Siyan; Lin, Stacie; Berube, Peter; Lee, Lia; Chen, Jenny; Brumbaugh, Justin; Rigollet, Philippe; Hochedlinger, Konrad; Jaenisch, Rudolf; Regev, Aviv; Lander, Eric S.

Cell ; 176(6): 1517, 2019 Mar 07.

Article in English | MEDLINE | ID: mdl-30849376

20.

Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.

Schwartz, Schraga; Bernstein, Douglas A; Mumbach, Maxwell R; Jovanovic, Marko; Herbst, Rebecca H; León-Ricardo, Brian X; Engreitz, Jesse M; Guttman, Mitchell; Satija, Rahul; Lander, Eric S; Fink, Gerald; Regev, Aviv.

Cell ; 159(1): 148-162, 2014 Sep 25.

Article in English | MEDLINE | ID: mdl-25219674

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Massively parallel base editing to map variant effects in human hematopoiesis.

Mapping transcriptomic vector fields of single cells.

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Efficient Generation of Transcriptomic Profiles by Random Composite Measurements.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Cohesin Loss Eliminates All Loop Domains.

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.

The Heroes of CRISPR.

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.

Convergence of coronary artery disease genes onto endothelial cell programs.

Development and applications of CRISPR-Cas9 for genome engineering.

RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.

Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.